REPLENISH Trial: combination capsule of estradiol and progesterone

The REPLENISH study, published in 2017, evaluated a new oral formulation combining estradiol and natural progesterone in a single gelatin capsule for the management of menopausal symptoms. It showed effective relief of vasomotor symptoms and good endometrial protection. Notably, the data suggested that using estradiol with natural progesterone carried a more favourable safety profile than traditional HRT containing synthetic progestogens, particularly in relation to breast and cardiovascular risk.

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