Studies - The Schoemann Clinic

Heart Research Institute, Australia (1999)

This study demonstrated that natural female hormones can help protect arteries by reducing the accumulation of fatty deposits that lead to the hardening and narrowing of blood vessels. In laboratory testing, oestrogen and progesterone reduced the amount of harmful lipid stored inside immune cells, an early step in artery thickening. These findings suggest that healthy hormone levels may play an essential role in supporting cardiovascular health in women. https://pubmed.ncbi.nlm.nih.gov/10587335/

Paulista State University, Brazil (2019)

The study found that post-menopausal women who have survived breast cancer face a higher risk of heart disease compared with women who have never had breast cancer. One reason may be that they are often unable to use HRT, missing out on the heart-protective benefits oestrogen can provide after menopause. https://pubmed.ncbi.nlm.nih.gov/31453965/

Leisure World Cohort Study, United States (2018)

Long-term research following thousands of women has shown that those who use oestrogen therapy after the menopause tend to live longer than those who do not. The most significant benefit was seen in women who stayed on treatment for many years. Overall, the findings suggest that continued oestrogen therapy may support healthier ageing and improve long-term survival. https://pmc.ncbi.nlm.nih.gov/articles/PMC7219089/

University of California Study, United States (1994)

This study examined men and women aged 40 to 70 who received a daily dose of DHEA for six months. Restoring DHEA to more youthful levels resulted in noticeable improvements in energy, mood, and overall sense of well-being, with more than two-thirds of participants feeling physically and emotionally better. Importantly, no significant side effects were reported, and measures such as body fat, insulin and cholesterol remained stable. The results suggest that DHEA can be a safe option that supports vitality and mental well-being as we age. https://pubmed.ncbi.nlm.nih.gov/7515387/

Vanderbilt University Study, United States (1989)

This study followed women using a daily combination of body-identical oestradiol and progesterone for one year. The results showed clear improvement in menopausal symptoms, better cholesterol profiles and minimal side effects. Most women had no unexpected bleeding and the treatment was well tolerated. Overall, the findings support body-identical HRT as a safe and effective option for symptom relief and long term health. https://pubmed.ncbi.nlm.nih.gov/2538787/

University of Amsterdam Study, the Netherlands (2005)

This study looked at people with hypothyroidism who still felt unwell despite taking standard thyroxine (T4). It found that adding a small amount of T3 to their treatment helped many patients feel better, even though formal test scores did not show significant differences. Notably, most participants preferred the combination of T4 and T3 over T4 alone. The findings suggest that for some individuals who continue to experience low thyroid symptoms, a carefully balanced mix of both hormones may offer better relief and improved day-to-day well-being. https://pubmed.ncbi.nlm.nih.gov/15705921/

Oestrogen and the Prevention of Degenerative Brain Disease, United States (2001)

Oestrogen is vital for brain health, supporting blood flow, reducing inflammation and helping nerve cells communicate effectively. As levels fall during the menopausal transition, many women notice changes in mood, memory and mental clarity. This study highlights that restoring oestrogen can support cognitive function and emotional well-being, offering protection for the brain as women age. https://pubmed.ncbi.nlm.nih.gov/11297335/

University of Western Australia Study (2007)

A study from the University of Western Australia looked at men aged 71 to 89 and found that those with clinically significant depression were much more likely to have low free testosterone levels. This association remained even after accounting for physical health issues, smoking, body weight and cognitive status. The findings imply that older men with persistent low mood might benefit from testosterone screening and, where appropriate, consideration of testosterone supplementation under medical supervision. https://pubmed.ncbi.nlm.nih.gov/18316674/

Testosterone Benefits for Women Study (1998)

A 1998 study found that restoring testosterone levels in women was associated with meaningful improvements in both sexual desire and overall well-being. Women receiving testosterone reported enhanced libido, greater energy and mood, and expressed a better sense of quality of life. The findings also suggest that a healthier bone structure, maintained by adequate hormone levels, may play a crucial role in protecting cardiovascular health over time. https://pubmed.ncbi.nlm.nih.gov/9785308/

Oral vs Transdermal Oestrogen. Retrospective Study Switzerland/United States (2021)

A large retrospective study from Switzerland and the United States, involving women aged 40 to 89, found no increased risk of blood clots in those using oral oestrogen compared with those using transdermal forms such as patches or gels. These findings offer reassurance that, for many women, oral oestrogen is a safe option when prescribed appropriately and monitored with good clinical oversight. https://pubmed.ncbi.nlm.nih.gov/34313612/

Elite Study, US (2026): Vascular Effects of Early versus Late Treatment with Estradiol – PubMed

This study showed that the timing of starting oestrogen therapy matters. Women who began treatment within the first few years after menopause experienced a slowing of artery thickening, suggesting a protective effect on the cardiovascular system. In women who started treatment much later, this benefit was not as pronounced. The findings support the idea that beginning oestrogen therapy earlier in the menopausal transition may offer better cardiovascular protection than waiting many years after menopause. https://pubmed.ncbi.nlm.nih.gov/27028912/

The REPLENISH Study, United States – ACOG (2017)

The REPLENISH study, published in 2017, evaluated a new oral formulation combining estradiol and natural progesterone in a single gelatin capsule for the management of menopausal symptoms. It showed effective relief of vasomotor symptoms and good endometrial protection. Notably, the data suggested that using estradiol with natural progesterone carried a more favourable safety profile than traditional HRT containing synthetic progestogens, particularly in relation to breast and cardiovascular risk. https://journals.lww.com/greenjournal/abstract/2017/05001/replenish_trial__combination_capsule_of.477.aspx

All Studies

Heart Research Institute, Australia (1999)

Paulista State University, Brazil (2019)

Leisure World Cohort Study, United States (2018)

University of California Study, United States (1994)

Vanderbilt University Study, United States (1989)

University of Amsterdam Study, the Netherlands (2005)

Oestrogen and the Prevention of Degenerative Brain Disease, United States (2001)

University of Western Australia Study (2007)

Testosterone Benefits for Women Study (1998)

Oral vs Transdermal Oestrogen. Retrospective Study Switzerland/United States (2021)

Elite Study, US (2026): Vascular Effects of Early versus Late Treatment with Estradiol – PubMed

The REPLENISH Study, United States – ACOG (2017)

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